Is there a link between statins and dementia?

Is there a link between statins and dementia?

Patients with statins had a significantly lower risk of developing all-type of dementia when compared with patients without statins. Biologically, it seems admissible that statins reduce the risk of dementia due to their lipid-lowering effect instead of other mechanism.

Can high cholesterol cause vascular dementia?

High blood cholesterol can raise the risk of certain types of dementia, such as Alzheimer’s disease and vascular dementia.

Do statins shorten your life?

“The focus at the time was primarily on people with high cholesterol, when in fact, even more people with normal cholesterol levels suffer a cardiac event over time. “The study showed that taking statins for 6 years reduced death from cardiovascular disease by 24 percent, and overall mortality by 23 percent.”

Is Crestor better than Lipitor?

The study concluded that Crestor lowered LDL cholesterol by 8.2% more than Lipitor, and Crestor lowered total cholesterol significantly more than all the other statins studied. Crestor also increased HDL cholesterol (the good kind of cholesterol) more than Lipitor did.

Does Crestor Cause Alzheimer’s?

That’s in contrast to hydrophilic statins — like rosuvastatin (Crestor) and pravastatin (Pravachol) — which act mainly in the liver. In this study, there was no link between those statins and increased dementia risk. The findings do not prove that lipophilic statins directly raise dementia risk, experts cautioned.

What is the function of SORL1 receptor?

SORL1 (neuronal sortilin-related receptor), located on chromosome 11q23.2-q24.2, is a member of the vacuolar protein sorting receptor family, which plays a role in trafficking and processing of APP [96].

What does SORLA stand for?

The sortilin-related receptor SORLA is an endocytic receptor that belongs to the vacuolar protein sorting 10 (VPS10) domain receptor family. SORLA binds to the amyloid precursor protein ( APP ).

What are cholesterol-lowering medications?

Some names are alirocumab and evolocumab This relatively new class of cholesterol-lowering medications works by preventing cholesterol from being absorbed in the intestine. Selective cholesterol absorption inhibitors are most effective at lowering LDL cholesterol.

Is SORLA a Type-1 transmembrane protein?

As a type-1 transmembrane protein, SORLA can undergo regulated intramembrane proteolysis and in the process shed a soluble ectodomain, but the physiological relevance of this fragment is unclear. Coming Into Vogue?